GP1BA monoclonal antibody, clone HIP1
产品名称: GP1BA monoclonal antibody, clone HIP1
英文名称: GP1BA monoclonal antibody, clone HIP1
产品编号: MAB0943
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native GP1BA.
- Immunogen:
- Native purified GP1BA from peripheral blood mononuclear cells of a patient suffering from CLL.
- Host:
- Mouse
- Theoretical MW (kDa):
- 135-145
- Reactivity:
- Human, Primates
- Specificity:
- This antibody reacts with CD42b (GPIb alpha), a 135-145 KDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 KDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
- Form:
- Liquid
- Purification:
- Protein A purification
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Immunohistochemistry (Frozen sections)
- Flow Cytometry
- Entrez GeneID:
- 2811
- Gene Name:
- GP1BA
- Gene Alias:
- BSS,CD42B,CD42b-alpha,GP1B,MGC34595
- Gene Description:
- glycoprotein Ib (platelet), alpha polypeptide
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq
- Other Designations:
- platelet glycoprotein Ib alpha polypeptide,platelet membrane glycoprotein 1b-alpha subunit
- Interactome
- Gene Pathway
- Related Disease
- Acute Chest Syndrome
- Acute Disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Aneurysm, Ruptured
- Angina, Unstable
- Antiphospholipid Syndrome
- Arterial Occlusive Diseases
- Arteriosclerosis
- Atherosclerosis
- Atherosclerosis
- Bernard-Soulier Syndrome
- Blood Platelet Disorders
- Brain Ischemia
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Carotid Artery Diseases
- Carotid Stenosis
- Cerebral Hemorrhage