FITC标记的血管生成素2抗体
产品名称： FITC标记的血管生成素2抗体
英文名称： Anti-Angiopoietin 2/FITC
产品编号： HZ-0677R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-Angiopoietin 2/FITC Conjugated antibody
FITC标记的血管生成素2抗体
| 英文名称 | Anti-Angiopoietin 2/FITC |
| 中文名称 | FITC标记的血管生成素2抗体 |
| 别 名 | AGPT 2; AGPT-2; Agpt2; ANG 2; ANG2; ANG-2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; Angiopoietin-2; ANGPT 2; ANGPT2; Tie2 ligand; ANGP2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Angiopoietin 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Subunit: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Subcellular Location: Secreted. Similarity: Contains 1 fibrinogen C-terminal domain. Database links: Entrez Gene: 285 Human Entrez Gene: 11601 Mouse Entrez Gene: 89805 Rat Omim: 601922 Human SwissProt: O15123 Human SwissProt: O35608 Mouse SwissProt: O35462 Rat Unigene: 583870 Human Unigene: 439874 Mouse Unigene: 138360 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血管生成素2(angiopoietin-2, Ang-2)是Ang家族的成员之一,是特异性血管生成刺激因子,也是恶性肿瘤早期的标志分子 |
由该基因编码的蛋白是血管生成素1（AngPT1）和内皮TEK酪氨酸激酶（TIE-2，TEK）的拮抗剂。编码的蛋白质破坏ANGPT1的血管重塑能力，并可能诱导内皮细胞凋亡。三个转录变体编码三个不同的异构体已经发现这个基因。[ RefSeq，JUL 2008 ]