神经纤毛蛋白1重组兔单克隆抗体-抗体-抗体-生物在线

神经纤毛蛋白1重组兔单克隆抗体

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产品名称：神经纤毛蛋白1重组兔单克隆抗体

英文名称： Neuropilin-1

产品编号： YJ-52933

产品价格： null

产品产地：上海

品牌商标：雅吉

更新时间： null

使用范围： WB, IF, ICC

上海雅吉生物科技有限公司

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产品详情

英文名称 Neuropilin-1
中文名称 神经纤毛蛋白1重组兔单克隆抗体
别 名 Neuropilin-1; NRP-1; Neuropilin1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHUMP00000020820; OTTHUMP00000020821; Vascular endothelial cell growth factor 165 receptor; VEGF165R; A5 protein; BLOOD DENDRITIC CELL ANTIGEN 4; NRP1_HUMAN.
研究领域 免疫学 神经生物学 生长因子和激素 细胞膜受体 内皮细胞
抗体来源 Rabbit
克隆类型 Monoclonal
克 隆 号 49H9
交叉反应 (predicted: Human, Mouse, Rat, )
产品应用 WB=1:1000-5000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
细胞定位 细胞膜 分泌型蛋白
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neuropilin-1:
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subunit:
Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Similarity:
Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.

SWISS:
O14786

Gene ID:
8829

Database links:
Entrez Gene: 8829 HumanEntrez Gene: 18186 Mouse
Entrez Gene: 246331 Rat
Omim: 602069 Human
SwissProt: O14786 Human
SwissProt: Q5T7F3 Human
SwissProt: P97333 Mouse
SwissProt: Q6PAR3 Mouse
SwissProt: Q9QWJ9 Rat
Unigene: 131704 Human
Unigene: 653996 Human
Unigene: 271745 Mouse
Unigene: 10815 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

英文名称	Neuropilin-1
中文名称	神经纤毛蛋白1重组兔单克隆抗体
别名	Neuropilin-1; NRP-1; Neuropilin1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHUMP00000020820; OTTHUMP00000020821; Vascular endothelial cell growth factor 165 receptor; VEGF165R; A5 protein; BLOOD DENDRITIC CELL ANTIGEN 4; NRP1_HUMAN.
研究领域	免疫学神经生物学生长因子和激素细胞膜受体内皮细胞
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	49H9
交叉反应	(predicted: Human, Mouse, Rat, )
产品应用	WB=1:1000-5000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	103kDa
细胞定位	细胞膜分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Neuropilin-1:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. Subunit: Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue Specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Similarity: Belongs to the neuropilin family. Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain. SWISS: O14786 Gene ID: 8829 Database links: Entrez Gene: 8829 Human Entrez Gene: 18186 Mouse Entrez Gene: 246331 Rat Omim: 602069 Human SwissProt: O14786 Human SwissProt: Q5T7F3 Human SwissProt: P97333 Mouse SwissProt: Q6PAR3 Mouse SwissProt: Q9QWJ9 Rat Unigene: 131704 Human Unigene: 653996 Human Unigene: 271745 Mouse Unigene: 10815 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.