FITC标记的髓鞘蛋白P0样蛋白1抗体-抗体-抗体-生物在线
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FITC标记的髓鞘蛋白P0样蛋白1抗体

FITC标记的髓鞘蛋白P0样蛋白1抗体

商家询价

产品名称： FITC标记的髓鞘蛋白P0样蛋白1抗体

英文名称： Anti-MPZL/FITC

产品编号： HZ-17744R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-MPZL/FITC Conjugated antibody

FITC标记的髓鞘蛋白P0样蛋白1抗体

 

英文名称 Anti-MPZL/FITC
中文名称 FITC标记的髓鞘蛋白P0样蛋白1抗体
别    名 immunoglobulin family transmembrane protein; MPZL1; MPZL1b; MPZL1_HUMAN; myelin protein zero like 1; myelin protein zero like protein 1 precursor; myelin protein zero like protein MPZL1b; OTTHUMP00000032519; protein zero related; PZR; PZR1b; PZRa; PZRb.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  信号转导  细胞粘附分a子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MPZL
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
MPZL1 is a 269 amino acid widely expressed single-pass type I membrane receptor belonging to the myelin P0 protein family and the immunoglobulin superfamily. MPZL2 (myelin protein zero-like 2), also known as EVA (epithelial V-like antigen) or EVA1, is a 215 amino acid single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain and two potential N-glycosylation sites in its extracellular domain, MPZL2 is expressed in thymus epithelium and is strongly down-regulated by thymocyte developmental progression. MPZL3 (myelin protein zero-like 3) is a 235 amino acid single-pass type I membrane protein that regulates homophilic cell-to-cell adhesion. A member of the myelin P0 protein family, MPZL3 contains one Ig-like V-type (immunoglobulin-like) domain and is expressed in brain, heart, liver and skin. g to the myelin P0 protein family and the immunoglobulin superfamily. Existing as four alternatively spliced isoforms, MPZL1 participates in signal transduction and cell migration.

Function:
Cell surface receptor, which is involved in signal transduction processes. Is a major receptor for concanavalin A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine protein kinases. Isoform 3 seems to block tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, unlike isoforms 2 and 3, may be involved in regulation of integrin mediated cell motility.

Subunit:
Interacts with phosphorylated PTPN11/SHP-2.

Subcellular Location:
Membrane; single pass type I membrane protein (Potential)

Tissue Specificity:
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.

Post-translational modifications:
Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
N-glycosylated. 

Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 

Database links:

Entrez Gene: 9019 Human

Omim: 604376 Human

SwissProt: O95297 Human

Unigene: 493919 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

mpzl1是一个269个氨基酸的广泛表达的单通I型膜受体属于髓磷脂P0蛋白家族和免疫球蛋白超家族。mpzl2（髓鞘蛋白零如2），也被称为伊娃（上皮V抗原）或EVA1，是一个215个氨基酸的单通I型膜蛋白，含有一个Ig样型（免疫球蛋白）域在其胞外结构域的两个潜在的糖基化位点，mpzl2表示胸腺上皮由胸腺细胞发育过程强烈下调。mpzl3（髓鞘蛋白零如3）是一个235个氨基酸的单通I型膜蛋白，调节同种细胞间的粘附性。的髓磷脂P0蛋白家族的一个成员，mpzl3包含一个Ig样型（免疫球蛋白）域和在脑、心脏表达，肝脏和皮肤。髓鞘P0蛋白家族和免疫球蛋白超家族。MPZL1作为四种交替剪接的亚型，参与信号转导和细胞迁移。