FITC标记的精神分裂症易感基因抗体
产品名称： FITC标记的精神分裂症易感基因抗体
英文名称： Anti-DTNBP1/FITC
产品编号： HZ-1561R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-DTNBP1/FITC Conjugated antibody
FITC标记的精神分裂症易感基因抗体
| 英文名称 | Anti-DTNBP1/FITC |
| 中文名称 | FITC标记的精神分裂症易感基因抗体 |
| 别 名 | Dysbindin-1; 5430437B18Rik; AW048963; dysbindin; sdy; DTNBP1; Dystrobrevin binding protein 1; Hermansky Pudlak syndrome 7 protein; HPS7; DTBP1_HUMAN; Dystrobrevin-binding protein-1; Hermansky-Pudlak syndrome 7 protein; HPS7 protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DTNBP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dysbindin may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC1), and binds to alpha and beta dystrobrevins, which are components of the dystrophin associated protein complex (DPC). Mutations in Dysbindin gene are associated with Hermansky-Pudlak syndrome type 7. Dysbindin gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Function: The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation Subcellular Location: Cytoplasm. Cytoplasmic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Endosome membrane. Melanosome membrane. Nucleus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Endoplasmic reticulum. Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at post-synaptic density, at pre-synaptic vesicle membranes and microtubules. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells. Tissue Specificity: Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3 (at protein level). Post-translational modifications: Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation. Phosphorylated by PRKDC. DISEASE: Defects in DTNBP1 are the cause of Hermansky-Pudlak syndrome type 7 (HPS7) [MIM:203300]. Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. Similarity: Belongs to the dysbindin family. Database links: Entrez Gene: 84062 Human Entrez Gene: 94245 Mouse Entrez Gene: 641528 Rat Omim: 607145 Human SwissProt: Q96EV8 Human SwissProt: Q91WZ8 Mouse SwissProt: Q5M834 Rat Unigene: 571148 Human Unigene: 352311 Mouse Unigene: 187290 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. dysbindin-1(DTNBP1)基因是一种精神分裂症的易感基因, 该基因实际上也是影响一般智力和认知能力相关的关键因素。因此研究人员认为DTNBP1在大脑细胞交流过程中扮演了一个重要的角色：帮助提升细胞存活度 |
Dybbin可能参与黑素体、血小板致密颗粒和溶酶体相关的细胞器生物合成。小鼠中的类似蛋白是溶酶体相关细胞器复合体1(BLOC1)的生物发生蛋白复合物的组成部分，并与α和βdystrobrevins结合，α和βdystrobrevins是dystrophin相关蛋白复合物(DPC)的组成部分。Dybin基因突变与Hurman 7型PurLak综合征相关。Dybin基因也可能与精神分裂症有关。编码该基因的多个转录变体编码不同的亚型。