FITC标记的组蛋白H3样抗体
产品名称： FITC标记的组蛋白H3样抗体
英文名称： Anti-Centromeric histone H3-like protein-2/FITC
产品编号： HZ-0483R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-Centromeric histone H3-like protein-2/FITC Conjugated antibody
FITC标记的组蛋白H3样抗体
| 英文名称 | Anti-Centromeric histone H3-like protein-2/FITC |
| 中文名称 | FITC标记的组蛋白H3样抗体 |
| 别 名 | centromere-specific H3 variant protein; Centromeric histone H3-like protein 2; Centromeric histone H3-like protein-2; cenp-A; A4PIF1_BRAJU. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 植物抗体 |
| 研究领域 | 肿瘤 免疫学 发育生物学 转录调节因子 植物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Brassica juncea |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Brassica juncea Centromeric histone H3-like protein-2 N-terminus |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
组蛋白是高度保守的蛋白质，作为结构核支架将细胞核DNA组织成染色质。四个核心组蛋白，H2A，H2B，H3，和H4，组装成八聚体（每个分子2个）。随后，146个碱基对包裹在八聚体周围，形成核小体，染色质的基本亚基。组蛋白修饰调节DNA转录、修复、重组和复制。最常用的修饰是乙酰化、磷酸化、甲基化和泛素化。这些修饰可改变局部染色质结构，或招募识别特异性组蛋白修饰的反式作用因子（“组蛋白密码”假说）。组蛋白H3在Lys9（H3K9ME3）上的三甲甲基化是最高度研究的表观遗传标记之一。H3K9ME3在真彩色基因的抑制中起作用，并且在异染色质组装的表观遗传控制中，最有可能通过作为染色质相关蛋白结合的识别基序，例如SWI6或HP1Alp/β。负责H3K9ME3形成的酶是SUV39 H1和SUV39 H2。