FITC标记的铁调节蛋白/铁调素抗体
产品名称： FITC标记的铁调节蛋白/铁调素抗体
英文名称： Anti-Hepcidin-25/FITC
产品编号： HZ-8870R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Hepcidin-25/FITC Conjugated antibody
FITC标记的铁调节蛋白/铁调素抗体
| 英文名称 | Anti-Hepcidin-25/FITC |
| 中文名称 | FITC标记的铁调节蛋白/铁调素抗体 |
| 别 名 | Hamp; HEPC; HEPC_RAT; HEPC_MOUSE; Hepc20; Hepc25; HEPCIDIN; Hepcidin; Hepcidin 20; Hepcidin 25; Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1; LEAP-1; LEAP1; Liver expressed antimicrobial peptide; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 2kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat Hepcidin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]. Subcellular Location: Secreted. Tissue Specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. DISEASE: Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:613313]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Similarity: Belongs to the hepcidin family. Database links: Entrez Gene: 57817 Human Entrez Gene: 84506 Mouse Entrez Gene: 84604 Rat Omim: 606464 Human SwissProt: P81172 Human SwissProt: Q9EQ21 Mouse SwissProt: Q99MH3 Rat Unigene: 8821 Human Unigene: 7865 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的产物参与维持铁稳态，对调节巨噬细胞中的铁储存和肠道铁吸收是必要的。前蛋白被翻译后切割成20、22和25个氨基酸的成熟肽，这些活性肽富含半胱氨酸，它们形成分子内键，稳定它们的β-片结构。这些肽具有抗菌活性。该基因的突变导致血色素沉着症2B，也称为青少年血色素沉着症，一种由严重铁超载引起的疾病，导致心肌病、肝硬化和内分泌衰竭。[ RefSeq，JUL 2008 ]提供。