STUB1 (C-term) Peptide
产品名称： STUB1 (C-term) Peptide
英文名称： STUB1 (C-term) Peptide
产品编号： P2063
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of STUB1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to amino acids 160-190 at C-terminus of human STUB1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
Peng HM, Morishima Y, Jenkins GJ, Dunbar AY, Lau M, Patterson C, Pratt WB, Osawa Y.J Biol Chem. 2004 Dec 17;279(51):52970-7. Epub 2004 Oct 4.
- 2.
- Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP.Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9.
- 3.
- The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.
Alberti S, Bohse K, Arndt V, Schmitz A, Hohfeld J.Mol Biol Cell. 2004 Sep;15(9):4003-10. Epub 2004 Jun 23.
- Applications
- Western Blot (Cell lysate)
- The STUB1 polyclonal antibody (Cat # PAB1693) is used in Western blot to detect STUB1 in HepG2 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with STUB1 polyclonal antibody (Cat # PAB1693) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 10273
- Protein Accession#:
- Q969U2
- Gene Name:
- STUB1
- Gene Alias:
- CHIP,HSPABP2,NY-CO-7,SDCCAG7,UBOX1
- Gene Description:
- STIP1 homology and U-box containing protein 1
- Omim ID:
- 607207
- Gene Ontology:
- Hyperlink
- Gene Summary:
- STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM
- Other Designations:
- heat shock protein A binding protein 2 (c-terminal),serologically defined colon cancer antigen 7
- Gene Pathway