RAD51AP1抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
RAD51AP1抗体

RAD51AP1抗体

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产品名称： RAD51AP1抗体

英文名称： RAD51AP1Antibody

产品编号： XY 11255-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 RAD51AP1抗体Applications

In-house applications ELISA, WB     Application not tested? Please see our Guarantee.
Species specificity Human, Mouse, Rat; other species not tested.
Images
Prev1NextView more validation data
  • 11255-1-AP;human brain tissuehuman brain tissue were subjected to SDS PAGE followed by western blot with 11255-1-AP(RAD51AP1 antibody) at dilution of 1:300
Positive WB detected in Human brain tissue, mouse liver tissue, rat liver tissue
Recommended dilution WB : 1:500-1:5000
 RAD51AP1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information RAD51AP1抗体
Immunogen RAD51AP1 fusion protein ag1781 Full name RAD51 associated protein 1
Calculated molecular
weight		 38 kDa Observed molecular 
weight		 38 kDa
GenBank accession 
number		 BC016330 Gene ID (NCBI) 10635
Gene symbol RAD51AP1 Synonyms PIR51, RAD51 associated protein 1, RAD51 interacting protein, RAD51AP1
Background

Homologous recombination (HR) is an important pathway for the elimination of DNA double-strand breaks (DSBs) and other deleterious lesions from chromosomes. The eukaryotic HR reaction is mediated by RAD51 [PMID:12456786]. RAD51AP1 (RAD51 associated protein 1), so named because it can interact with human RAD51, is a vertebrate-specific protein that enhances the ability of RAD51 to mediate the D-loop reaction. RAD51AP1 knockdown by siRNA leads to cellular sensitivity to DNA damaging agents and elevated DNA damage-induced chromatid breaks. Enhancement of the RAD51 recombinase activity by RAD51AP1 is contingent upon physical interaction of the two HR factors [PMID:17996710,17996711]. RAD51AP1抗体

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