FITC标记的G蛋白偶合受体激酶1抗体
产品名称： FITC标记的G蛋白偶合受体激酶1抗体
英文名称： Anti-GRK1/FITC
产品编号： HZ-1082R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-GRK1/FITC Conjugated antibody
FITC标记的G蛋白偶合受体激酶1抗体
| 英文名称 | Anti-GRK1/FITC |
| 中文名称 | FITC标记的G蛋白偶合受体激酶1抗体 |
| 别 名 | G-protein coupled receptor kinase 1; GRK1; GPRK1; RK; Grk1; Rhok; RHODOPSIN KINASE; RK_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 信号转导 激酶和磷酸酶 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRK1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq] Function: Phosphorylates rhodopsin thereby initiating its deactivation. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. Subcellular Location: Membrane. Tissue Specificity: Retina and pineal gland. Post-translational modifications: Autophosphorylated. Farnesylation is required for full activity. DISEASE: Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type 2 (CSNBO2) [MIM:613411]. It is non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. Database links: Entrez Gene: 6011 Human Entrez Gene: 24013 Mouse Omim: 180381 Human SwissProt: Q15835 Human SwissProt: Q9WVL4 Mouse Unigene: 103501 Human Unigene: 721727 Human Unigene: 257501 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. G蛋白偶联受体激酶1(GRK1)是催化激动剂诱导的GPCR磷酸化以及启动GPCR脱敏的关键激酶,主要用于GRK细胞膜转位和对GRK功能的影响. |
该基因编码Ser/Thr蛋白激酶家族中鸟嘌呤核苷酸结合蛋白(G蛋白)偶联受体激酶亚家族的成员。蛋白质磷酸化视紫红质并启动其失活。已知GRK1中的缺陷导致OguCI病2（也称为固定夜盲症OGUCHII型）。[由RefSeq提供]