MBS/MYPT1 (phospho T696) monoclonal antibody, clone AF-20
产品名称： MBS/MYPT1 (phospho T696) monoclonal antibody, clone AF-20
英文名称： MBS/MYPT1 (phospho T696) monoclonal antibody, clone AF-20
产品编号： MAB0001
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic phosphopeptide of MBS/MYPT1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T696 of human MBS/MYPT1.
- Host:
- Mouse
- Reactivity:
- Chicken, Human, Mouse, Rat
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 10 mM HEPES/KOH, 150 mM NaCl, pH 7.5 (50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Phospho-MBS/MYPT1 Thr696 Antibody detects endogenous MBS/MYPT1 only when phosphorylated at threonine696. The antibody does not recognize other myosin phosphatase regulatory subunit.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
ELISA (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Entrez GeneID:
- 4659
- GeneBank Accession#:
- D87930
- Protein Accession#:
- BAA22378
- Gene Name:
- PPP1R12A
- Gene Alias:
- MBS,MGC133042,MYPT1
- Gene Description:
- protein phosphatase 1, regulatory (inhibitor) subunit 12A
- Omim ID:
- 602021
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- myosin phosphatase, target subunit 1
- Related Disease