分子量:51 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Fumarase, His Tag by the LAL method.

Buffer:50 mM Tris, 150 mM NaCl, pH7.5

生物活性:

产品特性:Human Fumarase, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 51 kDa. The predicted N-terminus is Met. The reducing (R) protein migrates as 47 kDa in SDS-PAGE .

产品背景:Fumarate hydratase, mitochondrial is also known as Fumarase or FH, which belongs to the class-II fumarase/aspartase family and Fumarase subfamily. Fumarase is a homotetramer protein which is expressed in red blood cells. There are two substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. Fumarase also acts as a tumor suppressor.