COPS2/TRIP15抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
COPS2/TRIP15抗体

COPS2/TRIP15抗体

商家询价

产品名称： COPS2/TRIP15抗体

英文名称： COPS2/TRIP15Antibody

产品编号： XY10969-2

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 COPS2/TRIP15抗体

Applications
In-house applications ELISA, IHC, IF, IP, WB     Application not tested? Please see our Guarantee.
Published applications WB Publications 1 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Human
Images
Prev12NextView more validation data
  • 10969-2-AP;NIH/3T3 cellsIP Result of anti-COPS2 (IP:10969-2-AP, 3ug; Detection:10969-2-AP 1:500) with NIH/3T3 cells lysate 2500ug.
  • 10969-2-AP;human ovary tumorImmunohistochemical of paraffin-embedded human ovary tumor using 10969-2-AP(COPS2 antibody) at dilution of 1:50 (under 10x lens)
  • 10969-2-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 10969-2-AP( COPS2 Antibody) at dilution of 1:600
  • 10969-2-AP;HeLa cellsImmunofluorescent analysis of HeLa cells using 10969-2-AP( COPS2 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in HeLa cells, human brain tissue, mouse brain tissue, mouse skeletal muscle tissue, NIH/3T3 cells
Positive IP detected in NIH/3T3 cells
Positive IHC detected in Human ovary tumor tissue
Positive IF detected in HeLa cells
Recommended dilution WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100
 COPS2/TRIP15抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen COPS2/TRIP15 fusion protein ag1415 Full name COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
Calculated molecular
weight		 52 kDa Observed molecular 
weight		 52 kDa
GenBank accession 
number		 BC012629 Gene ID (NCBI) 9318
Gene symbol COPS2 Synonyms ALIEN, Alien homolog, COPS 2, COPS2, CSN2, SGN2, Signalosome subunit 2, TR interacting protein 15, TRIP 15, TRIP15
Background COPS2/TRIP15抗体

COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. (refer to UniProt) Catalog#10969-2-AP is a rabbit polyclonal antibody raised against the full-length of human COPS2. The MW of this protein is 52 kDa, and this antibody specially recognises the 52 kDa protein. COPS2/TRIP15抗体

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