FITC标记的NACA2蛋白抗体
产品名称： FITC标记的NACA2蛋白抗体
英文名称： Anti-NACA2/FITC
产品编号： HZ-18997R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NACA2/FITC Conjugated antibody
FITC标记的NACA2蛋白抗体
| 英文名称 | Anti-NACA2/FITC |
| 中文名称 | FITC标记的NACA2蛋白抗体 |
| 别 名 | Alpha NAC like; ANAC; Hom s 2.01; MGC71999; NAC alpha like; NACA2; NACAL; nascent polypeptide associated complex alpha polypeptide like; Nascent polypeptide associated complex subunit alpha 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NACA2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NACA2, Nascent polypeptide associated complex subunit alpha 2, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) by binding to nascent polypeptide chains as they emerge from the ribosome and blocking their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA2 also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) Subunit: Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Expressed specifically in testis and skeletal muscle. Similarity: Belongs to the NAC-alpha family. Contains 1 NAC-A/B (NAC-alpha/beta) domain. Contains 1 UBA domain. Database links: Entrez Gene: 342538 Human GenBank: NM_199290.3 Human Omim: 609274 Human SwissProt: Q9H009 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
naca2，新生多肽相关复杂的α亚基2、防止不恰当的目标非分泌性多肽的内质网（ER）结合到新生的多肽链作为他们摆脱核糖体和参与信号识别阻断作用LE（SRP），通常靶向新生分泌肽的ER。NaCa2还降低了在ER膜（M位点）中蛋白质易位位点的核糖体的固有亲和力。