FITC标记的紧密连接蛋白14抗体
产品名称： FITC标记的紧密连接蛋白14抗体
英文名称： Anti-Claudin 14/FITC
产品编号： HZ-10554R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Claudin 14/FITC Conjugated antibody
FITC标记的紧密连接蛋白14抗体
| 英文名称 | Anti-Claudin 14/FITC |
| 中文名称 | FITC标记的紧密连接蛋白14抗体 |
| 别 名 | Claudin-14; CLDN14; DFNB29; Human CLDN14 gene; OTTHUMP00000109046; OTTHUMP00000109049; OTTMUSP00000021531; UNQ777/PRO1571. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 14 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-14 is a multi-pass membrane protein that is expressed in liver, kidney and ear. Defects in the gene encoding claudin-14 are the cause of non-syndromic sensorineural deafness autosomal recessive type 29 (DFNB29), a form of hearing loss resulting from damage to either nerve pathways or neural receptors of the inner ear. Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Acts as a co-receptor for HCV entry into hepatic cells. Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity). May interact with HCV E1 and E2 proteins. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Tissue Specificity: Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. DISEASE: Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, vulgar type ichthyosis, and sclerosing cholangitis. Similarity: Belongs to the claudin family. Database links: Entrez Gene: 23562 Human Entrez Gene: 56173 Mouse Entrez Gene: 304073 Rat Omim: 605608 Human SwissProt: O95500 Human SwissProt: Q9Z0S3 Mouse Unigene: 660278 Human Unigene: 328716 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Claudin超家族由许多与结构相关的蛋白质组成。这些蛋白质是紧密连接在细胞旁运输中的重要结构和功能组分。在所有紧密连接的组织中，Caldin均位于上皮细胞和内皮细胞中。已知有三类蛋白质定位于紧密连接，包括克劳丁、闭锁素和结合粘附分子。由四个跨膜结构域和两个胞外环组成的紧密连接蛋白构成紧密的连接链。Claudin的表达通常高度局限于不同组织的特定区域，并且可能在通过紧密连接的跨细胞转运中发挥重要作用。CLUDIN 14是在肝脏、肾脏和耳朵中表达的多程膜蛋白。编码克劳丁-14的基因的缺陷是非综合征感音神经性耳聋常染色体隐性29型（DFNB29）的原因，这种类型是由于神经通路或内耳神经受体的损伤而引起的听力损失。