FITC标记的磷酸化电压门控性钾通道蛋白Kv4.2抗体
产品名称： FITC标记的磷酸化电压门控性钾通道蛋白Kv4.2抗体
英文名称： Anti-phospho-Kv4.2 (Thr607)/FITC
产品编号： HZ-20293R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-Kv4.2 (Thr607)/FITC Conjugated antibody
FITC标记的磷酸化电压门控性钾通道蛋白Kv4.2抗体
| 英文名称 | Anti-phospho-Kv4.2 (Thr607)/FITC |
| 中文名称 | FITC标记的磷酸化电压门控性钾通道蛋白Kv4.2抗体 |
| 别 名 | p-KCND2/Kv4.2(Thr607); p-Kv4.2(Thr607); Potassium voltage-gated channel subfamily D member 2; KCD2; KCND 2; KCND2; KCND2_HUMAN; KIAA1044; Potassium voltage gated channel Shal related subfamily member 2; RK 5; RK5; Voltage gated potassium channel Kv4.2; Voltage gated potassium channel subunit Kv4.2; Voltage sensitive potassium channel; voltage-gated potassium channel Kv4.2; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 心血管 神经生物学 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 70kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human KCND2 around the phosphorylation site of Thr607 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Subunit: Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10. Subcellular Location: Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression. Tissue Specificity: Highly expressed throughout the brain. Expression is very low or absent in other tissues. Post-translational modifications: Phosphorylated on serine and threonine residues. Similarity: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. Database links: Entrez Gene: 3751 Human Omim: 605410 Human SwissProt: Q9NZV8 Human Unigene: 654739 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
质膜中的电压门控K+通道控制神经元、肌肉和其他可兴奋细胞的复极和动作电位的频率。电压门控快速失活A型钾通道的孔形成（α）亚单位。可能有助于I（to）电流在心脏和I（SA）电流神经元。通道特性通过与其他α亚基和调节亚基的相互作用来调节。