HLA-A monoclonal antibody, clone W6/32
产品名称： HLA-A monoclonal antibody, clone W6/32
英文名称： HLA-A monoclonal antibody, clone W6/32
产品编号： MAB6449
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native HLA-A.
- Immunogen:
- Native purified HLA-A from membrane of human tonsil cells.
- Host:
- Mouse
- Reactivity:
- Bovine, Cat, Human, Non-Human Primates
- Specificity:
- This antibody recognizes MHC Class I molecules (MHC Class Ia) that are expressedon the surface of all human nucleated cell types. This antibody is also suitable as a positive control for HLA tissue typing andcrossmatching.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS, 300 mM NaCl, pH 7.4
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- A New Method for Rapid Cytotoxic T-lymphocyte Induction Using a Multiple Cytokine Cocktail.
Onishi H, Koya N, Kiyota A, Tanaka H, Umebayashi M, Katano M, Morisaki T.Anticancer Res. 2012 Jun;32(6):2385-90.
- 2.
- Expression of HLA-G in human cornea, an immune-privileged tissue.
Le Discorde M, Moreau P, Sabatier P, Legeais JM, Carosella ED.Hum Immunol. 2003 Nov;64(11):1039-44.
- 3.
- The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complex.
Tran TM, Ivanyi P, Hilgert I, Brdicka T, Pla M, Breur B, Flieger M, Ivaskova E, Horejsi V.Immunogenetics. 2001 Aug;53(6):440-6.
- 4.
- Residue 3 of beta2-microglobulin affects binding of class I MHC molecules by the W6/32 antibody.
Ladasky JJ, Shum BP, Canavez F, Seuanez HN, Parham P.Immunogenetics. 1999 Apr;49(4):312-20.
- Application Image
- Western Blot
- Immunohistochemistry (Frozen sections)
- Immunoprecipitation
- ELISA
- Functional Study
- Flow Cytometry
- enlarge
- Entrez GeneID:
- 3105
- Gene Name:
- HLA-A
- Gene Alias:
- HLAA
- Gene Description:
- major histocompatibility complex, class I, A
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq
- Other Designations:
- HLA class I histocompatibility antigen, A-23 alpha chain,MHC class I antigen HLA-A heavy chain,MHC leukocyte antigen,OTTHUMP00000161059,antigen presenting molecule,leucocyte antigen class I,leukocyte antigen class I-A
- Related Disease
- Abortion, Habitual
- Abruptio Placentae
- Acquired Immunodeficiency Syndrome
- Acute Disease
- Addison Disease
- Adenocarcinoma
- Adenovirus Infections, Human
- Agranulocytosis
- AIDS-Related Opportunistic Infections
- Alcoholism
- Alopecia Areata
- Alveolar Bone Loss
- Alzheimer Disease
- Alzheimer disease
- Anemia
- Anemia, Aplastic
- Aortic Aneurysm, Abdominal
- Aortic Diseases
- Arterial Occlusive Diseases