FITC标记的核仁同源蛋白17抗体
产品名称： FITC标记的核仁同源蛋白17抗体
英文名称： Anti-PIH1D1/FITC
产品编号： HZ-4273R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PIH1D1/FITC Conjugated antibody
FITC标记的核仁同源蛋白17抗体
| 英文名称 | Anti-PIH1D1/FITC |
| 中文名称 | FITC标记的核仁同源蛋白17抗体 |
| 别 名 | NOP17; Nucleolar protein 17 homolog; PIH1 domain containing 1; PIH1 domain containing protein 1; PIH1 domain-containing protein 1; PIH1D1; PIHD1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PIH1D1/NOP17 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PIH1D1 is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs (snoRNAs) during ribosomal biogenesis. SnoRNAs are associated in ribonucleoprotein particles localized to the nucleolus. Nop17 is a 290 amnio acid unstable protein that is stabilized through an interaction with HSP 90å/∫. Nop17 interacts with a core box C/D snoRNP protein Nop58, indicating a function of Nop17 in mediating the nucleolar retention or proper assembly of the box C/D snoRNP. A mutation in NOP17 gene may lead to a temperature-sensitive phenotype along with delocalization of key Nop proteins that are essential for snoRNP assembly. Similarity: Belongs to the PIH1 family. Database links: Entrez Gene: 55011 Human Omim: 611480 Human SwissProt: Q9NWS0 Human Unigene: 5245 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PIH1D1是在核糖体生物合成过程中与一类小核仁RNAs（SnRNNA）相关的一个系统性保守的蛋白质，用于有效地处理前rRNA。SnRNAS与核仁定位于核仁的颗粒相关。Nop17是一种290的羊水酸不稳定蛋白，通过与HSP（90）/II的相互作用而稳定。Nop17与核心盒C/D SnRNP蛋白Nop58相互作用，表明Nop17在介导盒C／D SnRNP的核仁保留或适当组装中起作用。NOP17基因的突变可能导致温度敏感表型以及关键NOP蛋白的离域化，这是SnNONP组装必不可少的。