TAP1 polyclonal antibody
产品名称： TAP1 polyclonal antibody
英文名称： TAP1 polyclonal antibody
产品编号： PAB4832
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TAP1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human TAP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases.
Lajoie J, Zijenah LS, Faucher MC, Ward BJ, Roger M.Hum Immunol. 2003 Aug;64(8):823-9.
- 2.
- Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
Gaudet R, Wiley DC.EMBO J. 2001 Sep 3;20(17):4964-72.
- 3.
- TAPI polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies.
Tang J, Freedman DO, Allen S, Karita E, Musonda R, Braga C, Margolick J, Kaslow RA.Hum Immunol. 2001 Mar;62(3):256-68.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of Jurkat cell lysate (35 ug/lane) with TAP1 polyclonal antibody (Cat # PAB4832).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with TAP1 polyclonal antibody (Cat # PAB4832) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 6890
- Protein Accession#:
- A41538;Q96CP4
- Gene Name:
- TAP1
- Gene Alias:
- ABC17,ABCB2,APT1,D6S114E,FLJ26666,FLJ41500,PSF1,RING4,TAP1*0102N,TAP1N
- Gene Description:
- transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq
- Other Designations:
- ABC transporter, MHC 1,ATP-binding cassette transporter,ATP-binding cassette, sub-family B (MDR/TAP), member 2,ATP-binding cassette, sub-family B, member 2,OTTHUMP00000029077,antigen peptide transporter 1,peptide supply factor 1,transporter 1, ATP-binding
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- Alveolitis, Extrinsic Allergic
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