SOX6,核转录因子SOX6抗体

产品编号HZ-11599R
英文名称SOX6
中文名称核转录因子SOX6抗体
别 名HSSOX 6; HSSOX6; SOX-6 SOX 6; SOX6_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
SOX6,核转录因子SOX6抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量92kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SOX6 (1-100aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SOX6,核转录因子SOX6抗体PubMedPubMed
产品介绍background:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

Function:
Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

Subunit:
Interacts with DAZAP2

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in a wide variety of tissues, most abundantly in skeletal muscle.

Post-translational modifications:
Sumoylation inhibits the transcriptional activity.

Similarity:
Contains 1 HMG box DNA-binding domain.

Database links:
UniProtKB/Swiss-Prot: P35712.3

SOX6,核转录因子SOX6抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.