BioXcell InVivoPlus anti-mouse CD8α克隆号YTS 169.4单克隆抗体能与小鼠CD8α反应。CD8抗原是一种跨膜糖蛋白，作为T细胞受体的共受体。与TCR一样，CD8与抗原呈递细胞(APC)展示的I类MHC分子结合。CD8主要在细胞毒性T细胞表面表达，但也可在胸腺细胞、自然杀伤细胞和一些树突状细胞亚群中发现。CD8最常见的存在形式是由一个CD8α和一个CD8β链组成的异二聚体，然而，它也可以是由两个CD8α链组成的同二聚体。CD8α和CD8β链均与免疫球蛋白可变轻链具有显著同源性。每个CD8链的分子量约为34 kDa。BioXcell InVivoPlus anti-mouse CD8α克隆号YTS 169.4抗体在体内使用时显示出depleting活性。
产品详情：
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产品名称 |
InVivoPlus anti-mouse CD8α |
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产品货号 |
BP0117 |
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产品规格 |
5/25/50/100mg |
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反应种属 |
Mouse |
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克隆号 |
YTS 169.4 |
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同种型 |
Rat IgG2b, κ |
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免疫原 |
CBA mouse thymocytes |
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实验应用 |
in vivo CD8+ T cell depletion |
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产品形式 |
PBS, pH 7.0,Contains no stabilizers or preservatives |
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纯度 |
>95%, Determined by SDS-PAGE |
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聚合 |
<5%, Determined by SEC |
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无菌处理 |
0.2 µm filtration |
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纯化方式 |
Protein G |
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RRID |
AB_10950145 |
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分子量 |
150 kDa |
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小鼠病原检测 |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
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保存条件 |
抗体原液保存在4°C，不能冷冻保存。 |
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推荐同型对照 |
InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin（货号BP0090） |
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推荐抗体稀释液 |
InVivoPure pH 7.0 Dilution Buffer（货号IP0070） |
为什么选择InVivoPlus抗体？
InVivoPlus级别的产品内毒素含量更低，经过多种实验验证，更适合用于体内实验研究
该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：
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应用 |
文章 |
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体内CD8+T细胞耗竭 (in vivo CD8+ T cell depletion) |
1. Vashist, N., et al. (2018). 'Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression' Front Immunol 9: 505. 2. Triplett, T. A., et al. (2018). 'Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' Nat Biotechnol 36(8): 758-764. 3. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity' Nature 521(7550): 99-104. 4. Burrack, K. S., et al. (2015). 'Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells' PLoS Pathog 11(10): e1005191. 5. Wensveen, F. M., et al. (2015). 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance' Nat Immunol 16(4): 376-385. 6. Li, Z., et al. (2015). 'Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' Transpl Immunol 33(2): 125-129. |
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